Buy Doxepin (Sinequan) capsules online

How and where to order Sinequan (Doxepin Hydrochloride) 10 mg, 25 mg, 75 mg pills online:

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Forms:	Doxepin HCl 10, 25, 75 mg capsules or tablets
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Indications and usage:

Sinequan (Doxepin Hydrochloride) is recommended for the treatment of:

Psychoneurotic patients with depression and/or anxiety.

Depression and/or anxiety associated with alcoholism (not to be taken concomitantly with alcohol).

Depression and/or anxiety associated with organic disease (the possibility of drug interaction should be considered if the patient is receiving other drugs concomitantly).

Psychotic depressive disorders with associated anxiety including involutional depression and manic-depressive disorders.

The target symptoms of psychoneurosis that respond particularly well to Sinequan include anxiety, tension, depression, somatic symptoms and concerns, sleep disturbances, guilt, lack of energy, fear, apprehension and worry.

Clinical experience has shown that doxepin capsules are safe and well tolerated even in the elderly patient. Owing to lack of clinical experience in the pediatric population, Sinequan (Doxepin HCl) pills are not recommended for use in children under 12 years of age.

Pharmacology:

The mechanism of action of doxepin is not definitely known. It is not a central nervous system stimulant nor a monoamine oxidase inhibitor. The current hypothesis is that the clinical effects are due, at least in part, to influences on the adrenergic activity at the synapses so that deactivation of norepinephrine by reuptake into the nerve terminals is prevented.

At clinical dosages up to 150 mg per day, Sinequan can be given to man concomitantly with guanethidine and related compounds without blocking the antihypertensive effect. At dosages above 150 mg per day blocking of the antihypertensive effect of these compounds has been reported.

This medication is virtually devoid of euphoria as a side effect. Characteristic of this type of compound, Doxepin HCl (Sinequan) has not been demonstrated to produce the physical tolerance or psychological dependence associated with addictive compounds.

Dosage and administration:

For most patients with illness of mild to moderate severity, a starting daily dose of 75 mg is recommended. Dosage may subsequently be increased or decreased at appropriate intervals and according to individual response. The usual optimum dose range is 75 mg/day to 150 mg/day.

In more severely ill patients higher doses may be required with subsequent gradual increase to 300 mg/day if necessary. Additional therapeutic effect is rarely to be obtained by exceeding a dose of 300 mg/day.

In patients with very mild symptomatology or emotional symptoms accompanying organic disease, lower doses may suffice. Some of these patients have been controlled on doses as low as 25–50 mg/day.

The total daily dosage of Doxepin Hydrochloride (Sinequan) capsules may be given on a divided or once-a-day dosage schedule. If the once-a-day schedule is employed, the maximum recommended dose is 150 mg/day. This dose may be given at bedtime. The 150 mg capsule strength is intended for maintenance therapy only and is not recommended for initiation of treatment.

Anti-anxiety effect is apparent before the antidepressant effect. Optimal antidepressant effect may not be evident for two to three weeks.

Dosage forms and strengths:

Sinequan (Doxepin Hydrochloride) capsules containing doxepin HCl equivalent to 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg.

Sinequan oral concentrate is available in 120 mL bottles with an accompanying dropper calibrated at 5 mg, 10 mg, 15 mg, 20 mg, and 25 mg. Each mL contains doxepin HCl equivalent to 10 mg doxepin.

Overdosage:

Deaths may occur from overdosage with doxepin and this class of drugs. Multiple drug ingestion (including alcohol) is common in deliberate tricyclic antidepressant overdose. As the management is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity develop rapidly after tricyclic antidepressant overdose; therefore, hospital monitoring is required as soon as possible.

Contraindications:

Sinequan is contraindicated:

in individuals who have shown hypersensitivity to the drug. Possibility of cross sensitivity with other dibenzoxepines should be kept in mind.

in patients with glaucoma or a tendency to urinary retention. These disorders should be ruled out, particularly in older patients.

Warnings and precautions:

Clinical worsening and suicide risk.

Screening patients for bipolar disorder.

Angle-closure glaucoma.

Adverse reactions, side effects:

Anticholinergic Effects: Dry mouth, blurred vision, constipation, and urinary retention have been reported. If they do not subside with continued therapy, or become severe, it may be necessary to reduce the dosage.

Central nervous system effects: drowsiness, confusion, disorientation, hallucinations, numbness, paresthesias, ataxia, extrapyramidal symptoms, seizures, tardive dyskinesia, tremor.

Cardiovascular: hypotension, hypertension, tachycardia.

Allergic: skin rash, edema, photosensitization, pruritus.

Hematologic: eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, purpura.

Gastrointestinal: nausea, vomiting, indigestion, taste disturbances, diarrhea, anorexia, aphthous stomatitis.

Endocrine: raised or lowered libido, testicular swelling, gynecomastia in males, enlargement of breasts and galactorrhea in the female, raising or lowering of blood sugar levels, syndrome of inappropriate antidiuretic hormone secretion.

Other: dizziness, tinnitus, weight gain, sweating, chills, fatigue, weakness, flushing, jaundice, alopecia, headache, exacerbation of asthma, angle closure glaucoma, mydriasis, hyperpyrexia.

Withdrawal symptoms: the possibility of development of withdrawal symptoms upon abrupt cessation of treatment after prolonged Sinequan administration should be borne in mind. These are not indicative of addiction and gradual withdrawal of medication should not cause these symptoms.

To report suspected adverse reactions of Sinequan (Doxepin Hydrochloride) capsules, contact Pfizer, Inc. pharmaceutical company or your local FDA.

Drug interactions:

Drugs metabolized by P450 2D6.

MAO inhibitors.

Cimetidine.

Alcohol.

Tolazamide.

Related medications:

Lamotrigine (Lamictal)

Diazepam for anxiety

Use in specific populations:

Pregnancy

Reproduction studies have been performed in rats, rabbits, monkeys and dogs and there was no evidence of harm to the animal fetus. The relevance to humans is not known. Since there is no experience in pregnant women who have received this drug, safety in pregnancy has not been established. There has been a report of apnea and drowsiness occurring in a nursing infant whose mother was taking Doxepin (Sinequan).

Pediatric use

The use of Sinequan in children under 12 years of age is not recommended because safe conditions for its use have not been established.

Geriatric use

The use of Doxepin capsules on a once-a-day dosage regimen in geriatric patients should be adjusted carefully based on the patient’s condition.

Where to buy doxepin online:

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Here is a list of popular medications containing doxepin as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

Trade name of the drug	Pharmaceutical forms and doses	Companies
Deptran	Capsules; Oral; Doxepin Hydrochloride 10 mg, 25 mg, 50 mg	Alphapharm
Quitaxon	Injectable; Injection; Doxepin Hydrochloride 12.5 mg / ml Solution; Oral; Doxepin Hydrochloride 10 mg / ml Tablets, Film-Coated; Oral; Doxepin Hydrochloride 10 mg, 50 mg	Lexphar Laboratoire Ercopharm Nepalm Laboratoires Roche
Silenor	Tablets; Oral; Doxepin Hydrochloride 3 mg, 6 mg	Currax Pharmaceuticals Somaxon Pharmaceuticals Paladin Laboratories Pernix Therapeutics Holdings
Sinequan	Capsules; Oral; Doxepin Hydrochloride 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg Concentrate; Oral; Doxepin Hydrochloride 10 mg / ml	Pfizer ERFA Farmasierra Primal Chemical Zuellig Pharma
Spectra	Capsules; Oral; Doxepin Hydrochloride 10 mg, 25 mg, 75 mg	Ranbaxy Solus Pharmaceuticals
Zonalon	Cream; Topical; Doxepin Hydrochloride 5%	Bradley Pharmaceuticals Delcor Asset Corporation Medicis Pharmaceutical Corporation Rafa Laboratories Valeant Pharmaceuticals

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